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On 3 November 2016, Alkarama alerted the United Nations Working Group on Enforced or Involuntary Disappearances (WGEID) of the case of Qadry Samy Zaky Abd Elrahman Muafy, a 49-year-old Egyptian citizen from Kafr Saad, Damietta Governorate who was abducted by members of the Police in Mit Ghamr, Dakahlia Governorate on 29 October 2016.

In late August 2016, the United Nations Working Group on Arbitrary Detention (WGAD), a group of independent experts, adopted Opinion n°42/2016; in which they qualify the detention of Ahmed Yousry Zaky, an Egyptian student who was arrested on 5 May 2015, as "arbitrary".

On 25 October 2016, Alkarama solicited the urgent intervention of the UN Working Group on Arbitrary Detention (WGAD) with regards to the final sentencing to 20 years in prison of former President Mohamed Morsi and other members of his staff, as a result of an Egyptian Court of Cassation's ruling on 22 October 2016.

On 19 October 2016, Alkarama referred to the United Nations Special Rapporteur on the Right to Health (SRH) the case of Ali Ahmed Ali Kerata, a 53-year-old employee who was arrested on 19 August 2014 in Damietta by members of the police forces falling under the Egyptian Ministry of Interior.

On 12 October 2016, Alkarama alerted the United Nations Working Group on Enforced or Involuntary Disappearances (WGEID) of several cases of disappearances in Egypt, concerning two young students, Ahmed Abdelrahim Hanafi Abdelrahim and Ahmed Atef Ahmed Abdelrahim Al Baghdadi, who recently went missing, as well as two men, Mohamed Gomaa Youssef Afifi and Abdelrahim Mahmoud Abd Annabi Alsayed, who have been disappeared for 10 months and two years respectively.

On 30 September 2016, Alkarama alerted the United Nations Working Group on Enforced or Involuntary Disappearances (WGEID) of the case of Ahmed Abdelrahman Ahmed Youssef Mabrouk, an Egyptian medical student who disappeared on 6 September.

On 8 September 2016, the Cabinet of Egypt approved an alarming draft NGO law that is currently under review by the Egyptian Council of State.

On 14 September 2016, Alkarama referred the case of Abdelrahman Gamal Mohamed Ahmed, an Egyptian medical student who disappeared on 25 August, to the United Nations Working Group on Enforced or Involuntary Disappearances (WGEID).

On 2 September 2016, Alkarama referred the case of Mohammad Mahmoud Sadeq Ahmed, an Egyptian lawyer who disappeared on 30 August, to the United Nations Working Group on Enforced or Involuntary Disappearances (WGEID). That day, Mahmoud Sadeq Ahmed was abducted by members of the police forces in Giza train station and has since gone missing, with the authorities refusing to provide information on him.

On 15 July 2016, Alkarama referred to the United Nations Working Group on Arbitrary Detention (WGAD) the case of Omar Mabrouk, a young student currently detained in Giza, Cairo, and facing an unfair trial. Held in incommunicado detention since his unlawful extradition from Kuwait to Egypt in October 2015 and until April 2016, he was severely tortured to confess crimes he never committed.